More and more doctors began to recognize the risk of blood stasis associated with bed rest. However, this treatment was not evidence-based. Strict bed rest had been considered as the cornerstone of treatment of acute DVT for a long period, not only because of the concern of possible dislodging thrombosis, but also the confinement to bed with 24 hours unfractionated heparin infusion. The first treatment of DVT can be dated back to 13 th century, and both medical and surgical therapies had been studied and adopted in the following centuries. Due to its relatively high incidence and possible fatal complications, the treatment of DVT has long been a major concern for many physicians and surgeons. DVT is a common disease, with the incidence being up to 0.5/1000 person-years.
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